2024
CCL19-positive lymph node stromal cells govern the onset of inflammatory arthritis via tropomyosin receptor kinase.
Schälter F, Azizov V, Frech M, Dürholz K, Schmid E, Hendel A, Sarfati I, Maeda Y, Sokolova M, Miyagawa I, Focke K, Sarter K, van Baarsen LGM, Krautwald S, Schett G, Zaiss MM.
Arthritis Rheumatol. 2024 Jun;76(6):857-868. doi: 10.1002/art.42807. Epub 2024 Mar 21. PMID: 38268500
Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model.
Stahl-Hennig C, Peter AS, Cordsmeier A, Stolte-Leeb N, Vestweber R, Socher E, Merida SA, Sauermann U, Bleyer M, Fraedrich K, Grunwald T, Winkler TH, Ensser A, Jäck H-M, Überla K.
J Virol. 2024 Jun 20:e0062824. doi: 10.1128/jvi.00628-24. Epub ahead of print. PMID: 38899895
Cell type-specific modulation of metabolic, immune-regulatory and anti-microbial pathways by CD101.
Wrage M, Holland T, Nüse B, Kaltwasser J, Fröhlich J, Arnold H, Gießler C, Flamann C, Bruns H, Berges J, Daniel C, Hoffmann MH, Anish C, Seeberger PH, Bogdan C, Dettmer K, Rauh M, Mattner J.
Mucosal Immunol. 2024 Jun 18:S1933-0219(24)00058-8. doi: 10.1016/j.mucimm.2024.06.004. Epub ahead of print. PMID: 38901763
Bispecific T cell engager therapy for refractory rheumatoid arthritis.
Bucci L, Hagen M, Rothe T, Raimondo MG, Fagni F, Tur C, Wirsching A, Wacker J, Wilhelm A, Auger JP, Pachowsky M, Eckstein M, Alivernini S, Zoli A, Krönke G, Uderhardt S, Bozec A, D’Agostino MA, Schett G, Grieshaber-Bouyer R.
Nat Med. 2024 Jun;30(6):1593-1601. doi: 10.1038/s41591-024-02964-1. Epub 2024 Apr 26. PMID: 38671240
Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual.
Kocher K, Moosmann C, Drost F, Schülein C, Irrgang P, Steininger P, Zhong J, Träger J, Spriewald B, Bock C, Busch DH, Bogdan C, Schubert B, Winkler TH, Tenbusch M, Schuster EM, Schober K.
Lancet Infect Dis. 2024 May;24(5):e272-e274. doi: 10.1016/S1473-3099(24)00134-8. Epub 2024 Mar 4. PMID: 38452777
IgG sialylation occurs in B cells pre antibody secretion.
Werner A, Hanić M, Zaitseva OO, Lauc G, Lux A, Nitschke L, Nimmerjahn F.
Front Immunol. 2024 May 17;15:1402000. doi: 10.3389/fimmu.2024.1402000. PMID: 38827747; PMCID:PMC11140079
Fiber rich food suppressed airway inflammation, GATA3 + Th2 cells, and FcεRIα+ eosinophils in asthma.
Schenzel A, Geiger A, Nendel E, Yang Z, Krammer S, Leberle A, Brunst AK,Trump S, Mittler S, Rauh M, Geppert CI, Tausche P, Hohenberger K, Rieker RJ, Schieweck O, Zundler S, Finotto S.
Front Nutr.2024 May 2;11:1367864. doi: 10.3389/fnut.2024.1367864. PMID: 38757128; PMC11097976
Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy.
Lischer C, Eberhardt M, Flamann C, Berges J, Güse E, Wessely A, Weich A, Retzlaff J, Dörrie J, Schaft N, Wiesinger M, März J, Schuler-Thurner B, Knorr H, Gupta S, Singh KP, Schuler G, Heppt MV, Koch EAT, van Kleef ND, Freen-van Heeren JJ, Turksma AW, Wolkenhauer O, Hohberger B, Berking C, Bruns H, Vera J
J Immunother Cancer. 2024 May 9;12(5):e008104. doi: 10.1136/jitc-2023-008104. PMID: 38724462; PMCID: PMC11086525
Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids.
Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G.
Nature. 2024 May;629(8010):184-192. doi: 10.1038/s41586-024-07282-7. Epub 2024 Apr 10. PMID: 38600378
Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.
Erkert L, Gamez-Belmonte R, Kabisch M, Schödel L, Patankar JV, Gonzalez-Acera M, Mahapatro M, Bao LL, Plattner C, Kühl AA, Shen J, Serneels L, De Strooper B; TRR241 IBDome Consortium; Neurath MF, Wirtz S, Becker C.
Gut. 2024 Apr 29:gutjnl-2023-331622. doi: 10.1136/gutjnl-2023-331622. Epub ahead of print. PMID: 38684238
Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery.
Lyu P, Wen J, Zhang W, Liu N, Stolzer I, Gießl A, Jia Y, Mauro D, Zhang F, Ciccia F, Soulat D, Günther C, Schett G, Bozec A.
Ann Rheum Dis. 2024 Mar 19:ard-2023-224491. doi: 10.1136/ard-2023-224491. Epub ahead of print. PMID: 38503474
GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity.
Bierling TEH, Gumann A, Ottmann SR, Schulz SR, Weckwerth L, Thomas J, Gessner A, Wichert M, Kuwert F, Rost F, Hauke M, Freudenreich T, Mielenz D, Jäck HM, Pracht K.
Cell Rep. 2024 Feb 27;43(2):113739. doi: 10.1016/j.celrep.2024.113739. Epub 2024 Feb 9. PMID: 38340319
Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.
Andreev D, Kachler K, Liu M, Chen Z, Krishnacoumar B, Ringer M, Frey S, Krönke G, Voehringer D, Schett G, Bozec A.
Nat Commun. 2024 Feb 5;15(1):1067. doi: 10.1038/s41467-024-45261-8. PMID: 38316791; PMCID: PMC10844633
CD19 CAR T-Cell Therapy in Autoimmune Disease – A Case Series with Follow-up.
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G.
N Engl J Med. 2024 Feb 22;390(8):687-700. doi: 10.1056/NEJMoa2308917. PMID: 38381673.
CAR T-cell therapy rescues adolescent with rapidly progressive lupus nephritis from haemodialysis.
Krickau, N. Naumann-Bartsch, M. Aigner, S. Kharboutli, S. Kretschmann, S. Spoerl, I. Vasova, S. Völkl, J. Woelfle, A. Mackensen, G. Schett, M. Metzler, F. Müller.
Lancet 2024; 403(10437):1627-1630
Tissue niche occupancy determines the contribution of fetal- versus bone-marrow-derived macrophages to IgG effector functions.
Wöhner M, Brechtelsbauer S, Friedrich N, Vorsatz C, Bulang J, Liang C, Schorr L, Beschin A, Guilliams M, Ravetch J, Nimmerjahn F, Biburger M
Cell Rep. 2024 Feb 27;43(2):113757. doi: 10.1016/j.celrep.2024.113757. Epub 2024 Feb 13. PMID: 38354088
L-arginine metabolism inhibits arthritis and inflammatory bone loss.
Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A.
Ann Rheum Dis. 2024 Jan 2;83(1):72-87. doi:10.1136/ard-2022-223626. PMID: 37775153
IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
Chiriac MT, Hracsko Z, Günther C, Gonzalez-Acera M, Atreya R, Stolzer I, Wittner L, Dressel A, Schickedanz L, Gamez-Belmonte R, Erkert L, Hundorfean G, Zundler S, Rath T, Vetrano S, Danese S, Sturm G, Trajanoski Z, Kühl AA, Siegmund B, Hartmann A, Wirtz S, Siebler J, Finotto S, Becker C, Neurath MF.
Gut. 2024 Jan 5;73(2):282-297. doi: 10.1136/gutjnl-2023-329628. PMID: 37884352
Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies.
Taubmann J, Knitza J, Müller F, Völkl S, Aigner M, Kleyer A, Gary R, Kretschmann S, Boeltz S, Atzinger A, Kuwert T, Roemer F, Uder M, Mackensen A, Schett G.
Rheumatology (Oxford). 2024 Jan 4;63(1):e12-e14. doi: 10.1093/rheumatology/kead330. PMID: 37432378; PMCID: PMC10765150
STAT6-induced production of mucus and resistin-like molecules in lung Club cells does not protect against helminth or influenza A virus infection.
Ruhl A, Antão AV, Dietschmann A, Radtke D, Tenbusch M, Voehringer D.
Eur J Immunol.2024 Jan;54(1):e2350558. doi: 10.1002/eji.202350558. Epub 2023 Oct 25. PMID: 37855177
2023
Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells.
Bergmann C, Müller F, Distler JHW, Györfi AH, Völkl S, Aigner M, Kretschmann S, Reimann H, Harrer T, Bayerl N, Boeltz S, Wirsching A, Taubmann J, Rösler W, Spriewald B, Wacker J, Atzinger A, Uder M, Kuwert T, Mackensen A, Schett G.
Ann Rheum Dis. 2023 Aug;82(8):1117-1120. doi: 10.1136/ard-2023-223952. Epub 2023 May 5. PMID: 37147112
Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis.
Zlatar L, Mahajan A, Muñoz-Becerra M, Weidner D, Bila G, Bilyy R, Titze J, Hoffmann MH, Schett G, Herrmann M, Steffen U, Muñoz LE, Knopf J.
Front Immunol. 2023 Aug 2;14:1174537. doi: 10.3389/fimmu.2023.1174537. PMID: 37600805; PMCID: PMC10433750
High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production.
Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte RV, Wirtz S, Tanaka Y, Winkler TH, Schett G, Soulat D, Bozec A.
Cell Rep. 2023 Jul 25;42(7):112713. doi: 10.1016/j.celrep.2023.112713. Epub 2023 Jul 7. PMID: 37421628; PMCID: PMC10391630
Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling.
Gamez-Belmonte R, Mahapatro M, Erkert L, Gonzalez-Acera M, Naschberger E, Yu Y, Tena-Garitaonaindia M, Patankar JV, Wagner Y, Podstawa E, Schödel L, Bubeck M, Neurath MF, Stürzl M, Becker C.
Gut. 2023 Jun;72(6):1155-1166. doi: 10.1136/gutjnl-2022-327323. Epub 2022 Oct 19. PMID: 36261293
Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes.
Culemann S, Knab K, Euler M, Wegner A, Garibagaoglu H, Ackermann J, Fischer K, Kienhöfer D, Crainiciuc G, Hahn J, Grüneboom A, Nimmerjahn F, Uderhardt S, Hidalgo A, Schett G, Hoffmann MH, Krönke G.
J Exp Med. 2023 Jun 5;220(6):e20220525. doi: 10.1084/jem.20220525. Epub 2023 Mar 28. PMID: 36976180
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1.
Seeling M, Pöhnl M, Kara S, Horstmann N, Riemer C, Wöhner M, Liang C, Brückner C, Eiring P, Werner A, Biburger M, Altmann L, Schneider M, Amon L, Lehmann CHK, Lee S, Kunz M, Dudziak D, Schett G, Bäuerle T, Lux A, Tuckermann J, Vögtle T, Nieswandt B, Sauer M, Böckmann RA, Nimmerjahn F.
Immunity. 2023 May 9;56(5):1046-1063.e7. doi: 10.1016/j.immuni.2023.02.019. Epub 2023 Mar 21. PMID: 36948194
A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages.
Hahn AM, Vogg L, Brey S, Schneider A, Schäfer S, Palmisano R, Pavlova A, Sandrock I, Tan L, Fichtner AS, Prinz I, Ravens S, Winkler TH.
Cell Rep. 2023 May 30;42(5):112558. doi: 10.1016/j.celrep.2023.112558.Epub 2023 May 13. Erratum for: Cell Rep. 2023 Mar 28;42(3):112253. PMID: 37182210.
The sphingosine-1-phosphate receptor agonist etrasimod in ulcerative colitis.
Atreya R, Neurath MF.
Lancet. 2023 Apr 8;401(10383):1132-1133. doi: 10.1016/S0140-6736(23)00228-3. Epub 2023 Mar 2. PMID: 36871570
Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.
Westermann S, Schubart C, Dietschmann A, Castiglione K, Radtke D, Voehringer D.
PLoS Pathog. 2023 Apr 5;19(4):e1011296. doi: 10.1371/journal.ppat.1011296. PMID: 37018382; PMCID: PMC10109486
CD19-targeted CAR T cells in refractory antisynthetase syndrome.
Müller F, Boeltz S, Knitza J, Aigner M, Völkl S, Kharboutli S, Reimann H, Taubmann J, Kretschmann S, Rösler W, Manger B, Wacker J, Mougiakakos D, Jabari S, Schröder R, Uder M, Roemer F, Krönke G, Mackensen A, Schett G.
Lancet. 2023 Mar 11;401(10379):815-818. doi: 10.1016/S0140-6736(23)00023-5. Epub 2023 Feb 15. PMID: 36930673
Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation.
Jeninga MD, Tang J, Selvarajah SA, Maier AG, Duffy MF, Petter M.
BMC Biol. 2023 Apr 3;21(1):65. doi: 10.1186/s12915-023-01568-4. PMID: 37013531; PMCID: PMC10071754.
Murine cytomegalovirus reactivation concomitant with acute graft-versus-host disease is controlled by antibodies.
Seefried M, Hundhausen N, Kroeger I, Büttner-Herold M, Hoffmann P, Edinger M, Ullrich E, Berberich-Siebelt F, Britt WJ, Mach M, Winkler TH.
JCI Insight. 2023 Mar 8;8(5):e149648. doi: 10.1172/jci.insight.149648. PMID: 36719764
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.
Martínez-Sánchez LDC, Ngo PA, Pradhan R, Becker LS, Boehringer D, Soteriou D, Kubankova M, Schweitzer C, Koch T, Thonn V, Erkert L, Stolzer I, Günther C, Becker C, Weigmann B, Klewer M, Daniel C, Amann K, Tenzer S, Atreya R, Bergo M, Brakebusch C, Watson AJM, Guck J, Fabry B, Atreya I, Neurath MF, López-Posadas R.
Gut. 2023 Feb;72(2):275-294. doi: 10.1136/gutjnl-2021-325520. Epub 2022 Mar 3. PMID: 35241625
Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.
Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R.
EMBO Mol Med. 2023 Feb 8;15(2):e15931. doi: 10.15252/emmm.202215931. Epub 2022 Dec 7. PMID: 36479617
IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity.
Schick J, Altunay M, Lacorcia M, Marschner N, Westermann S, Schluckebier J, Schubart C, Bodendorfer B, Christensen D, Alexander C, Wirtz S, Voehringer D, da Costa CP, Lang R.
Elife. 2023 Feb 8;12:e72923. doi: 10.7554/eLife.72923. PMID: 36753434; PMCID: PMC9908076
Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass.
Lai C, Heinemann J, Schleicher U, Schett G, Bogdan C, Bozec A, Soulat D.
J Bone Miner Res. 2023 Jan; 38(1):86-102. doi: 10.1002/jbmr.4733. Epub 2022 Nov 16. Erratum in: J Bone Miner Res. 2023 Dec;38(12):1907. PMID: 36332102.
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination.
Irrgang P, Gerling J, Kocher K, Lapuente D, Steininger P, Habenicht K, Wytopil M, Beileke S, Schäfer S, Zhong J, Ssebyatika G, Krey T, Falcone V, Schülein C, Peter AS, Nganou-Makamdop K, Hengel H, Held J, Bogdan C, Überla K, Schober K, Winkler TH, Tenbusch M.
Sci Immunol. 2023 Jan 27;8(79):eade2798. doi: 10.1126/sciimmunol.ade2798. Epub 2023 Jan 27. PMID: 36548397
2022
Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis.
Voskens C, Stoica D, Rosenberg M, Vitali F, Zundler S, Ganslmayer M, Knott H, Wiesinger M, Wunder J, Kummer M, Siegmund B, Schnoy E, Rath T, Hartmann A, Hackstein H, Schuler-Thurner B, Berking C, Schuler G, Atreya R, Neurath MF.
Gut. 2022 Apr 15:gutjnl-2022-327075. doi: 10.1136/gutjnl-2022-327075. Online ahead of print. PMID: 35428657
Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity.
Schwartz C, Schmidt V, Deinzer A, Hawerkamp HC, Hams E, Bayerlein J, Röger O, Bailer M, Krautz C, El Gendy A, Elshafei M, Heneghan HM, Hogan AE, O’Shea D, Fallon PG.
Sci Transl Med. 2022 Mar 9;14(635):eabj6879. doi: 10.1126/scitranslmed.abj6879. Epub 2022 Mar 9. PMID: 35263149
Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization.
Lapuente D, Fuchs J, Willar J, Vieira Antão A, Eberlein V, Uhlig N, Issmail L, Schmidt A, Oltmanns F, Peter AS, Mueller-Schmucker S, Irrgang P, Fraedrich K, Cara A, Hoffmann M, Pöhlmann S, Ensser A, Pertl C, Willert T, Thirion C, Grunwald T, Überla K, Tenbusch M.
Nat Commun. 2021 Nov 26;12(1):6871. doi: 10.1038/s41467-021-27063-4. PMID: 34836955
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.
Faas M, Ipseiz N, Ackermann J, Culemann S, Grüneboom A, Schröder F, Rothe T, Scholtysek C, Eberhardt M, Böttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, Wirtz S, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Krönke G. Immunity. 2021 Nov 9;54(11):2531-2546.e5. doi: 10.1016/j.immuni.2021.09.010. Epub 2021 Oct 12. PMID: 34644537
Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus.
Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G.
Nat Med. 2022 Oct;28(10):2124-2132. doi: 10.1038/s41591-022-02017-5. Epub 2022 Sep 15. PMID: 36109639
Organoids in gastrointestinal diseases: from experimental models to clinical translation.
Günther C, Winner B, Neurath MF, Stappenbeck TS.
Gut. 2022 Sep;71(9):1892-1908. doi: 10.1136/gutjnl-2021-326560. Epub 2022 May 30. PMID: 35636923
Towards preventive treatment of rheumatoid arthritis.
Rech J, Schett G.
Lancet. 2022 Jul 23;400(10348):253-255. doi: 10.1016/S0140-6736(22)01327-7. PMID: 35871801
The Gut-Immune-Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease.
Masanetz RK, Winkler J, Winner B, Günther C, Süß P.
Int J Mol Sci. 2022 Sep 21;23(19):11111. doi: 10.3390/ijms231911111. PMID: 36232412
An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons.
Krach F, Stemick J, Boerstler T, Weiss A, Lingos I, Reischl S, Meixner H, Ploetz S, Farrell M, Hehr U, Kohl Z, Winner B, Winkler J.
Nat Commun. 2022 Nov 10;13(1):6797. doi: 10.1038/s41467-022-34419-x. PMID: 36357392
Residual homing of α4β7-expressing β1+PI16+ regulatory T cells with potent suppressive activity correlates with exposure-efficacy of vedolizumab.
Becker E, Dedden M, Gall C, Wiendl M, Ekici AB, Schulz-Kuhnt A, Schweda A, Voskens C, Hegazy A, Vitali F, Atreya R, Müller TM, Atreya I, Neurath MF, Zundler S.
Gut. 2022 Aug;71(8):1551-1566. doi: 10.1136/gutjnl-2021-324868. Epub 2021 Aug 30. PMID: 34462337
2021
β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression.
Hofbauer D, Mougiakakos D, Broggini L, Zaiss M, Büttner-Herold M, Bach C, Spriewald B, Neumann F, Bisht S, Nolting J, Zeiser R, Hamarsheh S, Eberhardt M, Vera J, Visentin C, De Luca CMG, Moda F, Haskamp S, Flamann C, Böttcher M, Bitterer K, Völkl S, Mackensen A, Ricagno S, Bruns H.
Immunity. 2021 Aug 10;54(8):1772-1787.e9. doi: 10.1016/j.immuni.2021.07.002. Epub 2021 Jul 20. PMID: 34289378
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH.
Immunity. 2021 May 11;54(5):1002-1021.e10. doi: 10.1016/j.immuni.2021.03.003. Epub 2021 Mar 23. PMID: 33761330
Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis.
Neufert C, Heichler C, Brabletz T, Scheibe K, Boonsanay V, Greten FR, Neurath MF.
Nat Protoc. 2021 Jan;16(1):61-85. doi: 10.1038/s41596-020-00412-1. Epub 2020 Dec 14. PMID: 33318692
Gut as viral reservoir: lessons from gut viromes, HIV and COVID-19.
Neurath MF, Überla K, Ng SC.
Gut. 2021 Sep;70(9):1605-1608. doi: 10.1136/gutjnl-2021-324622. Epub 2021 Apr 26. PMID: 33903146
Electron phase-space control in photonic chip-based particle acceleration.
Shiloh R, Illmer J, Chlouba T, Yousefi P, Schönenberger N, Niedermayer U, Mittelbach A, Hommelhoff P.
Nature. 2021 Sep;597(7877):498-502. doi: 10.1038/s41586-021-03812-9. Epub 2021 Sep 22. PMID: 34552256
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.
Stolzer I, Schickedanz L, Chiriac MT, López-Posadas R, Grassl GA, Mattner J, Wirtz S, Winner B, Neurath MF, Günther C.
Mucosal Immunol. 2022 Jan;15(1):130-142. doi: 10.1038/s41385-021-00450-2. Epub 2021 Sep 8. PMID: 34497340
Charged particle guiding and beam splitting with auto-ponderomotive potentials on a chip.
Zimmermann R, Seidling M, Hommelhoff P.
Nat Commun. 2021 Jan 15;12(1):390. doi: 10.1038/s41467-020-20592-4. PMID: 33452245
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